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friedel crafts alkylation acylation

friedel crafts alkylation acylation

03 Jul 20261 min read

further chem
3.4.13 electrophilic substitution of benzene (HL) sear reactions

substrates:

  • benzene and activated benzenes
  • NO EWGs

pattern:

  • activation of electrophile with a Lewis acid
  • attack of the “activated” electrophile by the aromatic ring
  • deprotonation to restore aromaticity



beware rearrangements: hydride shift alkyl shift

e.g. propyl


mechanism later is same…
attack, deprotonate to restore aromaticity


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